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We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD).Polymorphisms of the CETPgene influence CETP activity and high-density lipoprotein (HDL) cholesterol concentration and might affect the long-term prognosis and response to statin therapy in patients with CAD...
To investigate antiatherosclerotic actions of nitric oxide (NO), experiments were performed in 4 groups of mice (n = 5/group) lacking functional LDL receptor genes (LDLR-ko). Group 1 was fed a regular chow diet. Groups 2 to 4 were fed a 1.25% high cholesterol Paigen diet; in addition, group 3 received supplemental L-arginine (arg) and group 4 received arg plus L-nitro arginine (LNA), an inhibitor...
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