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Using thyroid stimulant hormone (TSH) detection antibody-conjugated horseradish peroxidase (HRP) immobilized on platinum (Pt) nanoparticle, a highly sensitive biosensor designed based on the principle of 1,1′-oxalyldiimidazole chemiluminescent enzyme immune assay (ODI CLEIA) was developed for the early diagnosis of thyroid cancer. Trace levels of TSH in human serum was rapidly quantified with the...
Using the role of p-iodophenol in enzyme assay, enhanced 1,1′-oxalyldiimidazole chemiluminescent enzyme immunoassays (ODI-CLEIAs) were developed to consecutively quantify trace levels of triple tumor markers, such as alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), and prostate specific antigen (PSA) in a sample. Due to the high sensitivity of enhanced ODI-CLEIAs, it was possible to fix the...
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