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Obesity‐derived body mass may be detrimental to bone health through not well‐defined mechanisms. In this study we determined changes in bone structure and serum cytokines related to bone metabolism in diet‐induced obese mice. Mice fed a high‐fat diet (HFD) had higher serum tartrate‐resistant acid phosphatase (TRAP) and leptin but lower osteocalcin concentrations than those fed the normal‐fat diet...
Body mass has a positive effect on bone health. Whether mass derived from an obesity condition or excessive fat accumulation is beneficial to bone has not been established; neither have the mechanisms by which obesity affects bone metabolism. The aim of this study was to examine the effects of obesity on bone structure and osteoblastic expression of key markers involved in bone formation and resorption...
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