Wyniki wyszukiwania dla: Pinguan Zheng

Pozycje od 1 do 14 spośród 14 wyników

artykuł

Characterization of FlipIDAM as a SERT-selective SPECT imaging agent

Laetitia Lemoine, Brian P. Lieberman, Karl Ploessl, Pinguan Zheng, więcej

Nuclear Medicine and Biology > 2013 > 40 > 7 > 879-886

Biological evaluation of [ ¹²⁵ I]FlipIDAM (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol ([ ¹²⁵ I]4), a new single-photon emission computed tomography (SPECT) radioligand for imaging the serotonin transporter (SERT) which displayed improved in vivo kinetics for mapping SERT binding sites in the brain.In vitro binding studies of [ ¹²⁵ I]4 were performed with...

artykuł

A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [125I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol

Pinguan Zheng, Brian P. Lieberman, Karl Ploessl, Laetitia Lemoine, więcej

Bioorganic & Medicinal Chemistry Letters > 2013 > 23 > 3 > 869-872

New ligands for in vivo brain imaging of serotonin transporter (SERT) with single photon emission tomography (SPECT) were prepared and evaluated. An efficient synthesis and radiolabeling of a biphenylthiol, FLIP-IDAM, 4, was accomplished. The affinity of FLIP-IDAM was evaluated by an in vitro inhibitory binding assay using [ ¹²⁵ I]-IDAM as radioligand in rat brain tissue homogenates (K ...

artykuł

Carbon‐to‐Carbon Anion Relay Chemistry: Facile Generation of Substituted Allyllithium Species

Pinguan Zheng, Zhengxin Cai, Aswinkumar Garimallaprabhakaran, Parham Rooshenas, więcej

European Journal of Organic Chemistry > 2011 > 27 > 5255 - 5260

Treatment of [2‐(2‐bromophenyl)allyl]trimethylsilane with tBuLi in THF at –78 °C resulted in the rapid migration of the trimethylsilyl group to afford an allylic organolithium that can be easily trapped by a wide range of electrophiles. This is a rare example of a synthetically useful and efficientcarbon‐to‐carbon migration of a silicon group and represents a new approach to allylic organolithium...

artykuł

Carbon‐to‐Carbon Anion Relay Chemistry: Facile Generation of Substituted Allyllithium Species (Eur. J. Org. Chem. 27/2011)

Pinguan Zheng, Zhengxin Cai, Aswinkumar Garimallaprabhakaran, Parham Rooshenas, więcej

European Journal of Organic Chemistry > 2011 > 27 > n/a - n/a

The cover picture shows Columbia, Missouri's Activity & Recreation Center, whose acronym, ARC, fits perfectly with Anion Relay Chemistry, details of which are discussed in the article by P. R. Schreiner, M. Harmata et al. on p. 5255 ff. The cover was designed and assembled by Professor Harmata, and certain graphics were improved by Ms. Tammy McNiel.

artykuł

Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands

Pinguan Zheng, Brian P. Lieberman, Seok Rye Choi, Karl Plöessl, więcej

Bioorganic & Medicinal Chemistry Letters > 2011 > 21 > 11 > 3435-3438

In the search of new probes for in vivo brain imaging of vesicular monoamine transporter type 2 (VMAT2), we have developed an efficient synthesis of a novel series of 3-alkyl-dihydrotetrabenazine (DTBZ) derivatives. The affinity of VMAT2 was evaluated by an in vitro inhibitory binding assay using [ ¹²⁵ I]-iodovinyl-TBZ or [ ¹⁸ F](+)-FP-DTBZ as radioligands in rat striatal tissue homogenates...

artykuł

α,β‐Unsaturated Acyl Azoliums from N‐Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation

Jessada Mahatthananchai, Pinguan Zheng, Jeffrey W. Bode

Angewandte Chemie > 123 > 7 > 1711 - 1715

Auf frischer Tat ertappt: Acylazolium‐Ionen wurden seit langem als reaktive Zwischenstufen in Katalysen mit N‐heterocyclischen Carbenen vermutet, konnten unter Katalysebedingungen aber nie nachgewiesen werden. Dies ist jetzt gelungen, und α,β‐ungesättigte Acylazolium‐Zwischenstufen (siehe Schema) wurden mit verschiedenen spektroskopischen Methoden charakterisiert. Kinetische Messungen geben zudem...

artykuł

α,β‐Unsaturated Acyl Azoliums from N‐Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation

Jessada Mahatthananchai, Pinguan Zheng, Jeffrey W. Bode

Angewandte Chemie International Edition > 50 > 7 > 1673 - 1677

Caught in the act: Acyl azoliums have long been thought to be key reactive intermediates in N‐heterocyclic carbene catalysis, but they have never been observed under catalytic conditions. Now, this has been successfully achieved by the characterization of α,β‐unsaturated acyl azoliums (see scheme) using different spectroscopic techniques. Kinetic studies revealed the origin of their unexpected chemoselectivity...

artykuł

An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes

Juthanat Kaeobamrung, Jessada Mahatthananchai, Pinguan Zheng, Jeffrey W. Bode

Journal of the American Chemical Society > 2010 > 132 > 26 > 8810 - 8812

artykuł

A Stereospecific Synthesis of Chiral Cyclic Sulfinamides

Michael Harmata, Pinguan Zheng

Organic Letters > 2007 > 9 > 25 > 5251 - 5253

artykuł

Diastereoselectivity in an electrocyclization reaction of cyclopentadienones

Michael Harmata, Pinguan Zheng, Peter R. Schreiner, Armando Navarro-Vázquez

Tetrahedron Letters > 2007 > 48 > 33 > 5919-5922

Two cyclopentadienones were generated and both underwent conrotatory electrocyclization as expected based on Woodward–Hoffmann rules. This result lends support to the idea that these ring-closing reactions are, in fact, pericyclic processes.

artykuł

Expedient Synthesis of Sulfinamides from Sulfonyl Chlorides.

Michael Harmata, Pinguan Zheng, Chaofeng Huang, Maria G. Gomes, więcej

The Journal of Organic Chemistry > 2007 > 72 > 12 > 4586 - 4586

artykuł

Expedient Synthesis of Sulfinamides from Sulfonyl Chlorides

Michael Harmata, Pinguan Zheng, Chaofeng Huang, Maria G. Gomes, więcej

The Journal of Organic Chemistry > 2007 > 72 > 2 > 683 - 685

artykuł

ortho Substituent effect on a 1,5-H shift reaction during thermal decomposition of aryltriazenes

Michael Harmata, Xuechuan Hong, Pinguan Zheng

Tetrahedron Letters > 2006 > 47 > 41 > 7343-7347

An ortho substituent group has a significant effect on thermal decomposition of aryltriazenes. When the ortho methoxy-substituted phenyltriazenes were treated with methyl iodide at 110–130°C, 1,5-H shift products were obtained in fair to moderate yields.

artykuł

New Synthesis of Benzothiazines and Benzoisothiazoles Containing a Sulfoximine Functional Group

Michael Harmata, Kanok-on Rayanil, Maria G. Gomes, Pinguan Zheng, więcej

Organic Letters > 2005 > 7 > 1 > 143 - 145

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