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The investigation of impulsivity as a core marker of several major neuropsychiatric disorders has been greatly influenced by the therapeutic efficacy of drugs that block the reuptake of dopamine and noradrenaline in the brain. As a result, research into the neural mechanisms of impulsivity has focused on the catecholamine systems as the loci responsible for the expression of impulsive behaviour and...
Rationale Serotonin 2C (5-HT2C) receptors may play a role in regulating motivation and reward-related behaviours. To date, no studies have investigated the possible role of 5-HT2C receptors in ventral tegmental area (VTA) intracranial self-stimulation (ICSS). Objectives The current study investigated the hypotheses that 5-HT2C receptors play an inhibitory role in VTA ICSS, and that 5-HT2C receptors...
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