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The purpose of this work was to assess the immune response against plasmid DNA encoding hepatitis B virus (HBV) HBsAg in C57BL/6 mice inoculated by micro-needle. Fms-like tyrosine kinase 3 ligand (Flt3L), a hematopoietic growth factor, was used as an adjuvant. Immune response was determined by analysis of cytokine production. In addition, cytotoxic lymphocyte (CTL) activity was measured 7 days after...
To explore adjuvants that are capable of promoting Th1-biased immune response, we investigated the usefulness of levamisole (LMS) as one such adjuvant for two different preparations of killed viral vaccines, derived from the foot mouth disease virus (FMDV) or the porcine respiratory reproductive syndrome virus (PRRSV) and tested respectively in BALB/c or C57 BL/6 mice. The results showed that LMS...
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