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IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imparts their competence to be activated by TNFα. Mutations in the Drosophila IκBα gene cactus enhance...
Cell culture studies have established NF-κB's critical role in cancer cell survival and proliferation and led to the clinical use of NF-κB inhibitors. However, a paper in this issue of Cancer Cell reveals an anticancer function for NF-κB in a mouse model where NF-κB activity is lost specifically in hepatocytes. These studies suggest careful examination of NF-κB inhibitors as a therapeutic modality...
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