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Clinical guidelines continue to move away from routine prostate specific antigen screening (PSA), once a widespread medical practice. A curious difference exists between early prostate cancer and early breast cancer. While randomized trials of therapy in early breast cancer continue to show overall survival benefit, this is not the case in prostate cancer, where prostatectomy was no better than observation...
Cardiac risk stratification is the attempt to delineate who is at risk of cardiac event and who is not. Increasingly, the medical literature is filled with novel methods and markers of baseline risk assessment. This body of literature has been criticized broadly for making claims beyond what is statistically justified. In this hypothesis, we will explore an alterative explanation for the limitations...
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