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Msx1 and Msx2 encode homeodomain transcription factors that play a crucial role in limb development. However, the limb phenotype of the double Msx1null/nullMsx2null/null mutant is difficult to analyze, particularly along the anteroposterior axis, because of the complex effects of the double mutation on both ectoderm‐ and mesoderm‐derived structures. Namely, in the mutant, formation of the apical ectodermal...
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