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Objective
The 10‐year intensive lifestyle intervention (ILI) of the Look AHEAD study left a legacy of relative deficits in cognitive function among participants who entered the clinical trial with obesity or a history of cardiovascular disease. We hypothesized that altered levels of two weight‐sensitive proangiogenic cytokines, leptin and vascular endothelial growth factor (VEGF), accounted for this...
Objective
Recovery from weight regain is uncommon during weight loss treatment. This study examined whether participants in a weight gain prevention intervention similarly struggle to recover following weight gains and which factors predict transitions.
Methods
This is a secondary analysis of data from the Study of Novel Approaches to Weight Gain Prevention (SNAP), a randomized controlled trial...
Objective
This study aimed to determine the impact of weight gain prevention interventions on changes in cardiovascular risk factors over 6 years.
Methods
The Study of Novel Approaches to Weight Gain Prevention (SNAP) randomized 599 participants (ages 18‐35; 46% with BMI 21‐25; 54% with BMI 25‐30) to Large Changes (produce buffer by losing 5‐10 pounds initially), Small Changes (daily small changes...
Objective
The Action for Health in Diabetes (Look AHEAD) trial was a randomized trial comparing effects of intensive lifestyle intervention (ILI) and diabetes support and education (DSE) on cardiovascular disease (CVD) among individuals with overweight/obesity and type 2 diabetes. A secondary analysis was conducted to evaluate the association between change in weight and waist circumference (WC)...
Objective
This study was designed to determine whether intensive lifestyle intervention (ILI) aimed at weight loss lowers cancer incidence and mortality.
Methods
Data from the Look AHEAD trial were examined to investigate whether participants randomized to ILI designed for weight loss would have reduced overall cancer incidence, obesity‐related cancer incidence, and cancer mortality, as compared...
Objective
This study aimed to characterize young adults who experienced significant weight gains (> 10%) over 3 years in a weight gain prevention program.
Methods
Secondary data analysis from the Study of Novel Approaches to Weight Gain Prevention (SNAP), a randomized trial comparing two self‐regulation interventions and a control arm in young adults (18‐35 years; BMI 21‐30.9 kg/m2), was used...
Objective
The study objective was to determine whether two self‐regulation interventions that reduced 3‐year weight gain in young adults remain effective at 6 years.
Methods
A randomized trial was conducted in two academic settings in 599 young adults, aged 18 to 35 years, with normal weight or overweight; 504 (84%) reconsented for a 6‐year extension (Study of Novel Approaches to Weight Gain Prevention‐Extended [SNAP‐E])...
Objective
The Action for Health in Diabetes (Look AHEAD) research study was a randomized trial comparing the effects of an intensive lifestyle intervention (ILI) versus a diabetes support and education (DSE) control group in adults with type 2 diabetes and overweight or obesity. Functional magnetic resonance imaging was used to determine whether neural food cue reactivity differed for these groups...
Objective
Weight gain occurs commonly in young adults and increases the risk of cardiovascular disease (CVD). Following on a previous report that two self‐regulation interventions reduced weight gain relative to control, this study examines whether these interventions also benefit CVD risk factors.
Methods
The Study of Novel Approaches to Weight Gain Prevention was a randomized trial in two academic...
Objective
To assess the effect of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) on preference‐based health‐related quality of life (HRQOL) in persons with overweight or obesity and type 2 diabetes.
Methods
Look AHEAD was a multisite, randomized trial of 5,145 participants assigned to ILI or DSE. Four instruments were administered during the...
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