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Microbubbles (MBs) are widely used in clinical site as contrast agents in ultrasound imaging due to its eminent responsiveness to several MHz band. In recent years, ultrasound drug delivery system (DDS) using MBs are widely researched to achieve selective medication to the targeted diseased part. In the condition of high number density of bubbles to enhance the performance of DDS, it is essentially...
Microbubbles (MBs) are widely used in clinical site as contrast agents in ultrasound imaging due to its eminent responsiveness to several MHz band ultrasound. In recent years, ultrasound drug delivery system (DDS) using MBs are widely researched to achieve selective medication to the targeted diseased part. In the condition of high number density of bubbles to enhance the performance of DDS, it is...
Recently immunotherapy using therapeutic cells has attracted attention. Because the cells injected in human body disperse through the blood stream, there is a problem that small amount reaches to the diseased area. So we intend for in vivo cell delivery system, which is realized by attracting nanobubbles on the surface of cells to reduce its density for dynamic control of cells under ultrasound emission...
We have ever reported our attempts to control microbubbles (MBs) using the primary and secondary acoustic force for active control in artificial blood vessels. Recently, we have demonstrated active path selection of MBs by using a matrix array transducer to produce multiple focal points. On the other hand, bubble liposomes (BLs) have an advantage in easily modifying targeting ligand. However, considering...
Two types of gas-encapsulated liposomes (Bubble liposomes) with different shell compositions were evaluated by measurements of pressure-dependent ultrasound attenuation of bubble suspensions and by high-speed observations of bubble behaviors under exposure to pulsed ultrasound. Attenuation peaks were observed at the frequency range of 16-19 MHz, suggesting that the size of Bubble liposomes is around...
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