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Gastroesophageal reflux disease (GERD) is a chronic long-standing disease. Most patients with GERD are thought to require long-term treatment with acid suppressants, with proton pump inhibitors being the drugs of choice in managing these patients. However, there has been no consensus about the frequency of spontaneous remission of GERD. Furthermore, the duration of treatment is individually based,...
An 80-year-old man with diffuse esophageal spasm underwent high-resolution manometry perioperatively and postoperatively. Integrated relaxation pressure was normal, and distal latency and peristaltic waves had disappeared. Endoscopic ultrasound (EUS) revealed esophageal muscle layer thickening to more than 1 cm in an area spanning the esophagogastric junction to the oral side. Laparoscopic long myotomy...
Background Although jackhammer esophagus (JE) requires proper treatment, many aspects of its clinical course remain unknown. Method The 4 cases were in patients diagnosed with JE among the 447 patients who underwent high-resolution manometry (HRM) at our hospital between January 2009 and October 2014, and we assessed the patients’ background, their HRM, gastrointestinal endoscopy, and contrast...
Background This study aimed to evaluate risk factors for resistance to proton-pump inhibitor (PPI) therapy among patients with reflux esophagitis (RE) and nonerosive reflux disease (NERD) in gastroesophageal reflux disease (GERD) using a standardized questionnaire in Japan: the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG). Methods One hundred fifty-eight patients who...
A 64-year-old man underwent distal gastrectomy for gastric cancer. His postoperative recovery was uneventful until he suddenly started complaining of difficulty swallowing. Fluoroscopy revealed narrowing of the abdominal esophagus into a spindle-like shape. Endoscopic esophageal balloon dilatation was performed with no improvement in his condition. We concluded that the patient could not eat because...
We report a case of diffuse esophageal spasm (DES) successfully treated by esophageal long myotomy and Dor’s fundoplication. The patient was a 52-year-old man with a history of hepatitis C and severe chronic heart failure due to hypertensive cardiomyopathy. He had also undergone hemodialysis for chronic renal failure for 10 years. He had complained of dysphagia for 10 years. Diffuse esophageal spasm...
Background In Japan, the majority of patients with gastroesophageal reflux disease have low-grade reflux esophagitis (RE), including minimal changes, and the modified Los Angeles (LA) classification is widely used. However, there have been few evaluations of interobserver agreement with this classification. This study was performed to elucidate the level of interobserver agreement for diagnosis low-grade...
Background It is difficult to predict the optimal therapeutic medicine for each gastroesophageal reflux disease (GERD) patient. This study aimed to clarify the frequency scale for symptoms of GERD (FSSG) questionnaire, which predicts the requirement of proton pump inhibitor (PPI) maintenance therapy. Methods The subjects were 255 GERD patients (107 male, mean age 51.4 ± 16.5 years) with reflux symptoms...
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