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Transfusion of red blood cells (RBCs) is an effective therapy in surgery and critical care. Comparing to fresh RBCs, the therapeutic effect of stored RBCs is greatly limited because of its loss of NO during storage, which leads to vasodilatation dysfunction upon transfusion. So far, there is no effective solution to this problem. Here, we summarize the protective effects of Haptoglobin (Hp) in RBCs...
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