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ObjectiveThe mammalian target of rapamycin (mTOR) pathway has received increasing attention as a potential antiepileptogenic target. Treatment with the mTOR inhibitor rapamycin after status epilepticus reduces the development of epilepsy in a rat model. To study whether rapamycin mediates this effect via restoration of blood–brain barrier (BBB) dysfunction, contrast‐enhanced magnetic resonance imaging...
ObjectiveBlood–brain barrier (BBB) leakage may play a pro‐epileptogenic role after status epilepticus. In the accompanying contrast‐enhanced magnetic resonance imaging (CE‐MRI) study we showed that the mammalian target of rapamycin (mTOR) inhibitor rapamycin reduced BBB leakage and seizure activity during the chronic epileptic phase. Given rapamycin's role in growth and immune response, the potential...
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