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Tumor necrosis factor α (TNF-α) influences the pathogenesis of lung-fibrosis and carcinogenesis in normal cells. Polymorphisms of this gene are suggested to be associated with susceptibility to lung-diseases. Additionally TNF-α is postulated to play a significant role in regulating. Transforming growth factor (TGF-β 1 ) expression Therefore we investigated if the TNF-α or TGF-β 1 gene...
TNF-α is postulated to play a significant role in regulating TGF-β1 expression. In lung fibroblasts, for example, TNF-α is supposed to induce TGF-β1 via AP-1 activation. TNF-α receptor, knock-out mice are resistant to induced fibrosis and over-expression of TNF-α causes increased TGF-β1 production in mice. Therefore, we investigated whether TNF-α mRNA levels are associated with the TGF-β1 mRNA levels...
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