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Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance in ovarian cancer. To further explore the mechanism underlying NRF2‐dependent cisplatin resistance, we stably overexpressed or knocked down NRF2 in parental and cisplatin‐resistant human ovarian cancer cells, respectively. These two pairs of stable cell lines were then subjected to microarray analysis, where...
Interleukin‐8 (IL‐8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Overexpression of IL‐8 has been detected in many human tumors, including colorectal cancer (CRC), and is associated with poor prognosis. The goal of our study was to determine the role of IL‐8 overexpression in CRC cells in vitro and in vivo. We stably transfected the...
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