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The PAX4 gene, a member of the paired box (PAX) gene family, is thought to be involved in regulating the fate of β-cells in the mammalian pancreas. We observed the aberrant expression of PAX4 mRNA in 10 of 15 hematologic cell lines analyzed by RT-PCR. The restoration of PAX4 gene expression after treatment with the demethylating agent 5-aza-2′-deoxycitidine, as well as bisulfite sequencing analysis,...
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