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Combinational Photothermal‐Immunotherapy
In article number 2206441, Longjiang Zhang, Peng Huang, Zhongqiu Wang, and co‐workers load dual‐immune inhibitors nanomodulators for combinational photothermal‐immunotherapy through regulating abnormal enzymatic metabolism of IDO, blocking PD‐L1/PD‐1 and CD47/SIRPα to reverse immunosuppressive tumor microenvironment, and prevent tumor growth and re‐challenge...
Although photothermal therapy (PTT) can noninvasively kill tumor cells and exert synergistic immunological effects, the immune responses are usually harmed due to the lack of cytotoxic T cells (CTLs) pre‐infiltration and co‐existing of intricate immunosuppressive tumor microenvironment (TME), including the programmed cell death ligand 1 (PD‐L1)/cluster of differentiation 47 (CD47)/regulatory T cells...
Simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) can reduce the risks of drug leakage, body burden, and preparation complexity in traditional combination PDT/PTT. Here, a versatile nanoporphyrin (Pp18‐lipos) self‐assembled from lipid–purpurin 18 conjugates (Pp18‐lipids) and pure lipids is presented. The as‐prepared Pp18‐lipos with 2 mol% Pp18‐lipids can perform effective PDT...
In article number 2004481, Xiaobing Wang, Peng Huang, and co‐workers report the synthesis of a versatile nanoporphyrin (Pp18‐lipo) that is self‐assembled from lipid–purpurin 18 conjugates (Pp18–lipids) and pure lipids for multifunctional cancer theranostics. As‐prepared Pp18–lipos, with two different proportions of Pp18–lipids, simultaneously realize photoacoustic imaging, fluorescence imaging, magnetic...
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