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BackgroundL19‐TNF is a tumor‐targeting immunocytokine composed of the human L19 antibody binding to extra domain B (ED‐B) of fibronectin of newly formed blood vessels, and of human TNF. This exploratory trial evaluates safety and clinical activity of L19‐TNF plus melphalan‐containing isolated limb perfusion (ILP) in extremity melanoma patients.
MethodsSeven and 10 patients received 325 µg and 650...
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