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Notch signalling regulates stem cell development and survival and is deregulated in multiple malignancies. LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. We report the first-in-human phase I trial of LY900009.Dose escalation (Part A) was performed in cohorts of three advanced cancer patients using a modified continual reassessment method...
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