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The influenza A virus (IAV) PB2 subunit modulates viral polymerase activity, replication kinetics and pathogenicity. Here we identified novel PB2 substitutions at position 283 of H5 subtype IAV and evaluated their biological characteristics and virulence. The substitution PB2‐M283L enhanced the growth capacity and polymerase activity in human and mammalian cells in comparison to the rWT virus. The...
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