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The interaction of a moenomycin derivative with the enzyme penicillin binding protein 1b (PBP 1b) has been studied by means of STD NMR. The results obtained initiated the synthesis of a number of moenomycin derivatives modified in unit A including a moenomycin–ampicillin conjugate and determination of their antibiotic activities. A protocol is described that allows studying the interaction of moenomycin...
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