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The aim of this study was to investigate the pharmacokinetics of glibenclamide (Gli) administrated orally and intravenously to normal and diabetic rats. The AUC (0–720min) of orally administered Gli in diabetic rats (321.24mgmin/L) was greater than that (57.752mgmin/L) in normal rats. CL (0.019L/min/kg) was significantly slower than that (0.092L/min/kg) of normal rats. The AUC (0–480min)...
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