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AimsTo investigate effects of DNA methyltransferase (DNMT) inhibitors on dopaminergic neurons and its underlied mechanism.
MethodsThe DNMT inhibitor 5‐aza‐2′‐deoxycytidine (5‐aza‐dC) was tested in cultured dopaminergic cells. Cell viability and apoptosis were assayed with 5‐aza‐dC alone. Neurotoxicity of 1‐methyl‐4‐phenylpyridinium (MPP+), 6‐hydroxydopamine or rotenone was also assayed with 5‐aza‐dC...
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