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In the last decade, a search for alternative pest-control strategies has led to the development of genetically engineered microbial pesticides. Recombinants insect pathogens from the Baculoviridae family have been modified to express insect-specific toxins. The search for new insectotoxins has mostly focused on scorpion venoms. Our work on the venom of the Chinese scorpion Buthus martensi has led...
Tetrodotoxin was oxidized to a hydrated aldehyde, 11-oxo-tetrodotoxin, which shares the specificity of tetrodotoxin for the Na + channel of the isolated voltage-clamped frog skeletal muscle fiber, but is four to five times more potent. It binds to the solubilized Na + channel of eel electroplax with a similarly higher potency, because of an equilibrium dissociation constant about...
Currently used ligands for the voltage-gated sodium channel have shortcomings. A commercially available 3 H-saxitoxin has the 3 H on the C-11 methylene C from wich it can readily exchange with solvent H. A diffusely labelled 3 H-TTX with limited specific activity is not available commercially. Other non-commercial ligands are adducts of TTX, appreciably larger than TTX....
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