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We have made adamantylGSLs by substituting the fatty acids of primarily, globotriaosyl ceramide(Gb 3 ) and sulfogalactosyl ceramide(SGC), with the rigid α-adamantane hydrocarbon frame. These analogues have proven to be remarkably water-soluble but retain the receptor function of the parent membrane GSL. AdaGb 3 prevents the binding of verotoxins to target cells but increased pathology...
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