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Suicide gene therapy based on a combination of herpes simplex virus-thymidine kinase (HSV-tk) and ganciclovir (GCV) has obstacles to achieving a success in clinical use for the treatment of cancer due to inadequate thymidine kinase (TK) expression. The primary concern for improving anticancer efficacy of the suicide gene therapy is to develop an appropriate carrier that highly expresses TK in vivo...
Reducible poly(oligo-D-arginine) (rPOA) is a promising non-viral gene delivery carrier, providing lower cytotoxicity and higher gene expression efficiency compare to PEI. rPOA showed a higher level of HSV-TK gene expression in comparison with PEI in brain tumor cells and subsequently induced high cytotoxicity on tumor cells, in the presence of ganciclovir (GCV).
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