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TRAIL (tumor necrosis factor–related apoptosis-inducing ligand) preferentially induces apoptosis of cancer cells without toxicity in normal cells. TRAIL plays an important role in host immunosurveillance against tumor metastasis. Cathepsin B (CB) is a mediator of apoptosis whose activity is regulated by inhibitors known as cystatins (CY).To relate the TRAIL sensitivity of clonally related primary...
Neurofibromatosis 1 (NF1) is an autosomal-dominantly inherited genetic disorder caused by a spectrum of mutations affecting the NF1 gene, a gene located at 17q11.2 and spanning more than 350 kilobases. Affected patients develop a number of benign and malignant tumors at an increased frequency. Clinical findings include multiple café-au-lait spots, neurofibromas, axillary freckling, optic gliomas,...
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