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Background and Aims
Increasing evidence in recent years has suggested that microRNA‐7 (miR‐7) is an important gene implicated in the development of various diseases including HCC. However, the role of miR‐7 in autoimmune hepatitis (AIH) is unknown.
Approach and Results
Herein, we showed that miR‐7 deficiency led to exacerbated pathology in Concanavalin‐A‐induced murine acute autoimmune liver injury...
We assessed the risk of chronic kidney disease (CKD) in chronic hepatitis C virus (HCV)‐infected patients and the incidence reduction of CKD after receipt of HCV treatment. We also evaluated the risk of membranoproliferative glomerulonephritis (MPGN) and cryoglobulinemia in chronic HCV patients. A retrospective cohort analysis of the Truven Health MarketScan Database (2008‐2015) in the United States...
Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs (miRNAs) could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR‐21 and efficient and sustained inhibition of miR‐21 by using highly hepatic tropic adeno‐associated virus...
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