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Aims
The purpose of this study was to explore pharmacokinetic and pharmacodynamic aspects of a contemporary dosing scheme of cefuroxime as perioperative prophylaxis in cardiac surgery using cardiopulmonary bypass (CPB).
Methods
Cefuroxime plasma concentrations were measured in 23 patients. A 1.5‐g dose of cefuroxime was administered at start of surgery and CPB, followed by 3 additional doses every...
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