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Traumatic brain injury (TBI) is caused by mechanical forces, producing tissue deformation at the moment of injury. Complex cellular, neurochemical and metabolic alterations are initiated by the deformation and result in delayed cell death and dysfunction. Using an in vitro model of TBI based on organotypic brain slice cultures, we have quantitatively studied the relationship between tissue deformation...
Traumatic brain injury (TBI) is caused by in response to mechanical loading of the head. An extended biological cascade is initiated by the deformation and results in delayed cell death and dysfunction. Using an in vitro model of TBI based on organotypic brain slice cultures, we have quantitatively studied the relationship between tissue deformation and outcome. In the current study, we asked the...
Essential components of a stretchable microelectrode array (SMEA) to record from biological tissue include: a compliant and elastic substrate, stretchable conductors forming active electrodes and traces, and an electrical insulation layer. The materials and architecture of these SMEA components must be biocompatible, resistant to electrolytic environments, and electrically functional during and after...
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