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Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. For this randomised, open-label, pilot study, we recruited patients aged 19–65 years with euthymic bipolar I disorder from the Mood Disorder...
Although mania and hypomania define bipolar disorder, depressive episodes are more common and impairing, with few proven treatments. Adjunctive therapy with second-generation antidepressants is widely used to treat acute bipolar depression, but their efficacy and safety remain controversial. In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register...
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