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Treatment of pancreatic cancer with gemcitabine (GEM) is limited due to its rapid plasma metabolism and development of chemoresistance. MicroRNA (miRNA) regulates cancer stem cell (CSC) maintenance and induces chemoresistance in cancer cells. In this study, we observed differential downregulation of miR-205 (miR-205-5p) in human pancreatic cancer tissues and cells. Compared to GEM-sensitive MIA PaCa-2...
We report here paramagnetic dysprosium nanomaterial-based T 2 MRI contrast agents. A large r 2 and a negligible r 1 is an ideal condition for T 2 MR imaging. At this condition, protons are strongly and nearly exclusively induced for T 2 MR imaging. The dysprosium nanomaterials fairly satisfy this because they are found to possess a decent r 2 but a negligible...
The water-soluble d-glucuronic acid coated ultrasmall Eu 2 O 3 nanoparticles with particle diameters ranging from 1.0 to 3.0nm and with a hydrodynamic diameter of 4.71nm were synthesized in one-pot solution phase reaction and their fluorescent imaging properties were characterized in vitro and in vivo. They showed a strong fluorescence in the red region, a high photostability, a narrow...
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