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Background
Inhibiting catechol‐O‐methyltransferase extends the plasma half‐life of levodopa, potentially allowing physicians to optimize the levodopa regimen in patients with Parkinson's disease (PD) experiencing motor fluctuations.
Objectives
To evaluate the effects of once‐daily opicapone on levodopa plasma pharmacokinetics and motor response when added to two different levodopa dosing regimens...