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We previously observed highly rapid and robust response of murine olfactory receptor S6 (mOR-S6) with chimeric Gα 15_olf , compared to Gα 15 . To identify residues responsible for this difference in response, mutations of the cytosolic helix 8 were analyzed in a heterologous functional expression system. The N-terminal hydrophobic core between helix 8 and TM1–2 of mOR-S6 is important...
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