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Luteolin is a flavonoid found in many fruits, vegetables, and herbs. The antiinflammatory effects of luteolin have been reported. In this study, the effect of luteolin on allergic diseases and the underlying molecular mechanism were investigated. We found that luteolin inhibits Fc epsilon RΙ (FcεRΙ)‐ and Mas‐related G protein‐coupled receptor X2 (MRGPRX2)‐mediated mast cells (MCs) activation, including...