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Enhancer of zeste homolog 2 (EZH2) catalyses histone H3 lysine 27 trimethylation (H3K27me3) to silence tumour‐suppressor genes in hepatocellular carcinoma (HCC) but the process of locus‐specific recruitment remains elusive. Here we investigated the transcription factors involved and the molecular consequences in HCC development. The genome‐wide distribution of H3K27me3 was determined by chromatin...
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