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G protein-coupled receptor 40 (GPR40) is believed to be an attractive target to enhance insulin secretion in patients with type 2 diabetes. GPR40 has been found to couple to Gq protein, leading to the activation of phospholipase C and subsequent increases in the intracellular Ca2+ level. However, the underlying mechanisms that regulate the internalization and desensitization of GPR40 remain to be...
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