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The premyofibril model proposes a three‐stage process for the de novo assembly of myofibrils in cardiac and skeletal muscles: premyofibrils to nascent myofibrils to mature myofibrils. FRAP experiments and jasplakinolide, a drug that stabilizes F‐actin, permitted us to determine how decreasing the dynamics of actin filaments affected the dynamics of tropomyosin, troponin‐T, troponin‐C, and two Z‐Band...
ArgBP2 (Arg/Abl‐Binding Protein) is expressed at high levels in the heart and is localized in the Z‐bands of mature myofibrils. ArgBP2 is a member of a small family of proteins that also includes vinexin and CAP (c‐Cbl‐associated protein), all characterized by having one sorbin homology (SOHO) domain and three C‐terminal SH3 domains. Antibodies directed against ArgBP2 also react with the Z‐bodies...
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