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Little is known about the optimal management of patients with chronic hepatitis B (CHB) who developed multiple-drug resistance.We assessed 91 patients with compensated CHB who developed adefovir-resistant mutations during adefovir monotherapy for lamivudine-resistant CHB. Of these, 41 were treated with a combination of lamivudine plus adefovir (LAM+ADV group) and 50 were treated with entecavir monotherapy...
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