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The activation of hepatitis B virus (HBV)‐related hepatitis is associated with both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). We analyzed the association between the immune response and changes in the proportion of Pre‐S deletion variants. We quantified Pre‐S deleted HBV (HBV‐del) and wild‐type HBV (HBV‐wt) DNA levels in sera obtained from HBV‐infected mice and chronic hepatitis...
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