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Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation‐induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide,...
Intervertebral Disc Degeneration
In article number 2308167, Pooyan Makvandi, Yunlong Zhou, Aimin Wu, and co‐workers prepared a multifunctional metal polyphenol nanoparticle that exhibited the ability to escape lysosomal capture and effectively targeted mitochondria to scavenge excess reactive oxygen species. The results of in vitro and in vivo experiments showed that the nanoparticles retarded disc...
Coupling hollow semiconductor with metal–organic frameworks (MOFs) holds great promise for constructing high‐efficient CO2 photoreduction systems. However, energy band mismatch between them makes it difficult to exert their advantages to maximize the overall photocatalytic efficiency, since that the blockage of desirable interfacial charge transfer gives rise to the enrichment of photoelectrons and...
The pursuit of single‐assembled molecular cage reactors for complex tandem reactions is a long‐standing target in biomimetic catalysis but still a grand challenge. Herein, nanozyme‐like organic cages are reported by engineering air‐stable radicals into the skeleton upon photoinduced electron transfer. The generation of radicals is accompanied by single‐crystal structural transformation and exhibits...
Target therapy for highly heterogeneous cancers represents a major clinical challenge due to the lack of recurrent therapeutic targets identified in these tumors. Herein, the authors report a tumor‐customized targeting photothermal therapy (PTT) strategy for highly heterogeneous cancers, by which 2D supramolecular self‐assembled nanodiscs are modified with tumor‐specific binding peptides identified...
Photothermal Therapy
In article number 2200179, Xuesheng Jiang, Xiaohua Yu, Zhaoming Ye, and co‐workers introduce a strategy of precise photothermal therapy for highly heterogenous cancers by a tumor‐customized 2D supramolecular nanodisc (T‐ND). By modifying Cy7‐TCF crystal with phage display derived tumor‐customized binding peptides, T‐ND shows excellent photothermal efficacy to ablate the tumor...
Herein, the assembly of 3D uniform gear‐like architectures is demonstrated with a tobacco mosaic virus (TMV) disk as a building block. In this context, the intrinsic behavior of the TMV disk that promotes its assembly into nanotubes is altered by a synergistic effect of dual functional modifications at the 53rd arginine mutation and the introduction of lysine groups in the periphery at 1st and 158th...
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