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AimDuring type 1 diabetes (T1D), the medullary thick ascending limb (mTAL) displays an NADPH oxidase‐dependent increase in sodium transport, in concert with increased NO production by NO synthase 1 (NOS1) and NOS2. We hypothesized that NOS1‐ and/or NOS2‐derived NO blunts T1D‐induced activation of sodium transport in the mTAL.
MethodsT1D was induced by streptozotocin injection (STZ rats); sham rats...
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