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Purpose
Explore impact of dual angiopoietin‐2 (Ang‐2)/vascular endothelial growth factor‐A (VEGF‐A) targeting by faricimab on vessel destabilisation and retinal inflammation in 2 mouse models: retinal ischaemia/reperfusion (I/R) injury model to assess vascular permeability, and JR5558 spontaneous choroidal neovascularisation (sCNV) model to investigate inflammation, in the context of phase 2/3 clinical...
Purpose
To explore the vessel stabilisation potential of dual angiopoietin‐2 (Ang‐2)/vascular endothelial growth factor‐A (VEGF‐A) inhibition in a mouse model of spontaneous choroidal neovascularisation (sCNV) in the context of phase 2 clinical data on faricimab, a bispecific antibody that binds to and neutralises both Ang‐2 and VEGF‐A.
Methods
Seven‐week‐old JR5558 mice, developing sCNV in both...
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