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A vast majority of the cardioprotective properties exhibited by High‐Density Lipoprotein (HDL) is mediated by its major protein component Apolipoprotein A‐I (ApoA1). In order to develop a simplified bioprocess for producing recombinant human Apolipoprotein A‐I (rhApoA1) in its near‐native form, rhApoA1was expressed without the use of an affinity tag in view of its potential therapeutic applications...
Hepcidin was first identified as an antimicrobial peptide present in human serum and urine. It was later demonstrated that hepcidin is the long-sought hormone that regulates iron homeostasis in mammals. Recombinant human Hepcidin-25 (Hepc25) was expressed in Pichia pastoris using a modified version of the pPICZαA vector. Hepc25 was then purified by a simple two-step chromatographic process to obtain...
Neck dissection is recommended for patients with head and neck cutaneous melanoma and nodal metastasis. However, there appears to be no clear evidence to guide the extent of nodal resection.Loco-regional recurrence (LR), overall survival (OS) and progression free survival (PFS) was retrospectively compared between patients who had Comprehensive neck dissection (CND) and Selective neck dissection (SND)...
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