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ObjectiveExcessive glucocorticoid treatment increases the incidence of osteopenia and osteonecrosis. MicroRNAs (miRNAs) reportedly target messenger RNA expression and regulate osteoblastogenesis and skeletal development. We undertook this study to investigate whether miR‐29a regulates glucocorticoid‐mediated bone loss.
MethodsRats were given methylprednisolone, lentivirus‐mediated miR‐29a precursor,...
ObjectiveProlonged glucocorticoid treatment increases the risk of osteopenic disorders. Bone loss and marrow fat accumulation are prominent features of glucocorticoid‐induced skeletal destruction. Cannabinoid receptor 1 (CB1) has been found to regulate energy expenditure and adipose tissue lipogenesis. We undertook this study to investigate whether CB1 signaling regulates glucocorticoid‐induced bone...
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