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The locus control region (LCR) is the most important cis-element in the regulation of β-globin gene expression. DNaseI-hypersensitive site (HS) 2 and HS3 are two significant components of β-LCR. To examine the effect of HS2, HS3, and HS2-HS3 (combination of HS2 and HS3) on the spatial and temporal expression of the human β-globin gene, we have produced transgenic mice with constructs, in which the...
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