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Memory access latency continues to be a dominant bottleneck in a large class of applications on modern architectures. To optimize memory performance, it is important to utilize the locality in the memory hierarchy. Structure splitting can significantly improve memory locality. However, pinpointing inefficient code and providing insightful guidance for structure splitting is challenging. Existing tools...
Goal: The existing ISFET-based DNA sequencing detects hydrogen ions released during the polymerization of DNA strands on microbeads, which are scattered into microwell array above the ISFET sensor with unknown distribution. However, false pH detection happens at empty microwells due to crosstalk from neighboring microbeads. In this paper, a dual-mode CMOS ISFET sensor is proposed to have accurate...
This paper presents a high-gain and large-scale CMOS ion-sensitive field effect transistor (ISFET) sensor. The high-gain readout is achieved by a novel pH-to-Time-to-Voltage conversion (pH-TVC), which can greatly increase pixel density (small pixel size) with a high sensitivity. The proposed pH sensor consists of 512×576 pixel array with 3.9um×3.9um chemical sensing area, and is integrated with column-paralleled...
Memory hierarchies in modern computer systems are complex; often, they include multi-level caches and multiple memory controllers on the same chip. Without careful design, programs suffer from unnecessary data movement between caches and memory, degrading performance and increasing energy consumption. Array regrouping can significantly improve data locality by improving spatial reuse of data and reducing...
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