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This paper presents a high-gain and large-scale CMOS ion-sensitive field effect transistor (ISFET) sensor. The high-gain readout is achieved by a novel pH-to-Time-to-Voltage conversion (pH-TVC), which can greatly increase pixel density (small pixel size) with a high sensitivity. The proposed pH sensor consists of 512×576 pixel array with 3.9um×3.9um chemical sensing area, and is integrated with column-paralleled...
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