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Akt is a serine/threonine protein kinase, a critical mediator of growth factor‐induced survival in key cellular pathways. Allosteric signaling between protein intramolecular domains requires long‐range communication mediated by hotspot residues, often triggered by ligand binding. Here, based on extensive 3 μs explicit solvent molecular dynamics (MD) simulations of Akt1 kinase domain in the unbound...
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